Nurse-led Coping and Support for TNBC patients moving to survivorship
Official title: A Nurse-Led, Coping and Supportive Care Intervention to Improve Psychosocial Outcomes of Patients with Triple-Negative Breast Cancer During the Transition from Curative Therapy to Surveillance
Funded at Massachusetts General Hospital · NIH-11365935 · Data updated 2026-11-12
A nurse-led program called TRANSITIONS helps women with triple-negative breast cancer manage distress and fear as they enter surveillance after curative treatment.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 17, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $252,186 |
| NIH project number | 5K08CA286755-03 |
| Project ID | NIH-11365935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with triple-negative breast cancer transitioning from curative therapy to surveillance.
✕Less likely to help
Patients without TNBC or those not transitioning to survivorship care may not benefit from this program.
What this research studies
This project aims to create a nurse-driven coping and supportive care approach for TNBC patients during the shift from active treatment to routine follow-up. It will build on patient and stakeholder input, refine the program, and test it in a small pilot study. If feasible and acceptable, the team plans a randomized trial to explore preliminary benefits on psychosocial outcomes. The work will be conducted at Mass General and affiliated community sites over five years.
Why it matters
Potential benefit: If successful, TNBC patients may experience less anxiety and better emotional support during survivorship.
How similar studies have gone: There is a gap in targeted coping and supportive care interventions for TNBC during survivorship, making this largely novel in this specific patient group.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Post, Kathryn Elizabeth — Massachusetts General Hospital
- Study coordinator: Post, Kathryn Elizabeth
Related research
Other NIH-funded projects on the same topics.
-
Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry
This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.
-
Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans
A study aims to block two cancer-promoting pathways (IL-6 and CDK4/6) to prevent or reduce progression of triple-negative breast cancer in women veterans.
-
Linking heavy metal exposure to a tougher breast cancer type (TNBC)
Aimed at understanding how heavy metals like cadmium might trigger a dangerous breast cancer type (TNBC) in people, especially those with BRCA1 risk, to identify possible future treatment strategies.
-
Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate
Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.
-
Rac-enhanced CAR-Macrophages against TNBC
A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.
-
A new peptide therapy to help treat metastatic triple-negative breast cancer
A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.