Noninvasive imaging endpoints for uveitis readiness
Official title: Noninvasive, Trial-Ready Multimodal Imaging Endpoints for Uveitis
Funded at University of California at Davis · NIH-11442820 · Data updated 2026-11-12
A planning project to build noninvasive imaging tools and a shared method for measuring inflammation in noninfectious uveitis to prepare for a future trial.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 4, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $483,000 |
| NIH project number | 1R34EY039557-01 |
| Project ID | NIH-11442820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with noninfectious uveitis treated at academic medical centers could be suitable candidates once a future trial opens.
✕Less likely to help
Patients without uveitis or those not involved in future trials would not directly benefit from this planning grant.
What this research studies
This grant focuses on making uveitis trials easier and safer by using noninvasive eye imaging instead of the current invasive dye test. It will create a standardized way to measure inflammation using OCT and wide-field imaging, and build a multicenter data repository to harmonize images and annotations. A machine-learning system will learn to predict inflammation levels from these images, with careful checks for interpretability and clinical usefulness. The project will finalize procedures, data pipelines, and a small feasibility study to ensure readiness for a future randomized trial.
Why it matters
Potential benefit: If successful, patients with uveitis could participate in future trials more easily and benefit from noninvasive monitoring that reduces risk and complexity.
How similar studies have gone: Previous work in ocular imaging has shown promise in noninvasive endpoints, but this project aims to standardize and validate them for trials, which is still being actively developed.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Emami-Naeini, Parisa — University of California at Davis
- Study coordinator: Emami-Naeini, Parisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.