NIH-funded research NIH-funded research

Noninvasive brain stimulation for chronic pain relief

Official title: CRP: Noninvasive brain stimulation for chronic pain treatment

Funded at Highland Instruments, INC. · NIH-11395320 · Data updated 2026-11-12

A study to test a noninvasive brain stimulation approach to help people with chronic low back pain feel less pain.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionHighland Instruments, INC.
NIH-funded
Lab location1 site (Cambridge, United States)
Project startAugust 20, 2025
Project endApril 30, 2027
Funding year2026
Award (this year)$1,916,568
NIH project number5SB1AG091887-02
Project IDNIH-11395320 on NIH RePORTER

Who could benefit from this research

Could help

Adults with chronic low back pain refractory to conventional therapies.

Less likely to help

People whose pain does not respond to brain stimulation or experience adverse effects would not benefit.

What this research studies

This project explores a brain-focused treatment that aims to reduce chronic low back pain using noninvasive stimulation. Researchers will work with adults who have long-standing back pain that hasn’t improved with standard care. The study will involve safe, noninvasive procedures and track changes in pain levels and daily function over time. Participants may receive follow-up assessments to understand how well this approach works for managing chronic pain.

Why it matters

Potential benefit: If successful, patients could experience reduced pain and improved daily functioning without invasive procedures.

How similar studies have gone: Past noninvasive brain stimulation studies have shown mixed but promising results for chronic pain.

Where this research is happening

  • Highland Instruments, INC.
    Cambridge, United States
    Active

Researchers

  • Principal investigator: Dipietro, Laura — Highland Instruments, INC.
  • Study coordinator: Dipietro, Laura

Related research

Other NIH-funded projects on the same topics.

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    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

  • Understanding how to use pharmacogenomic testing to guide chronic pain care

    This grant looks at how doctors who treat long‑term pain decide when and how to use genetic testing to tailor pain medicines for safer and more effective care.

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  • Mindfulness and Self-Hypnosis for Pain in Older Adults

    This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.

    NIH research University of Washington · Seattle, United States · NIH-11599794

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.