Non-invasive brain-m mapping to guide cancer surgery
Official title: Non-invasive neurosurgical planning with Random Matrix Theory MRI
Funded at Microstructure Imaging, INC. · NIH-11407450 · Data updated 2026-11-12
A non-invasive MRI method using Random Matrix Theory aims to improve brain tumor surgery planning so surgeons can safely remove more tumor while sparing critical brain regions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microstructure Imaging, INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 22, 2021 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,137,424 |
| NIH project number | 2R44CA257624-02 |
| Project ID | NIH-11407450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with primary malignant brain tumors or brain metastases who may benefit from surgical planning using non-invasive MRI mapping.
✕Less likely to help
Patients who cannot undergo MRI or whose tumors are not near functional brain areas may see limited benefit.
What this research studies
This project focuses on making advanced MRI brain mapping work reliably across different MRI machines, so doctors can plan tumor surgery without invasive awake procedures. By improving image quality and automating brain mapping, it strives to fit into routine care at multiple hospitals. The goal is to help patients with brain cancers achieve safer, more effective tumor removal and better outcomes.
Why it matters
Potential benefit: If successful, patients could benefit from more precise tumor removal with fewer neurological side effects and better chances of longer survival.
How similar studies have gone: Prior work showed a 4x SNR improvement with MICSI-RMT, suggesting potential for real-world clinical gains, though broader validation is ongoing.
Where this research is happening
-
Microstructure Imaging, INC.
New York, United States Active
Researchers
- Principal investigator: Lemberskiy, Grigoriy — Microstructure Imaging, INC.
- Study coordinator: Lemberskiy, Grigoriy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.