Nighttime blood pressure and heart risk in children with proteinuric kidney disease
Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)
This project looks at how nighttime blood pressure and sleep patterns relate to heart and blood vessel damage in children with proteinuric kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11300196 on NIH RePORTER |
What this research studies
You or your child would be followed over time with overnight ambulatory blood pressure monitoring and sleep measurements to look for nighttime blood pressure problems. The researchers will collect blood and other samples to study gene activity (transcriptomics) linked to these nighttime blood pressure changes. They will also check heart and blood vessel health to see if nighttime blood pressure issues lead to target organ damage. All data will be analyzed to find clinical signs and molecular markers that might help spot children at higher cardiovascular risk earlier.
Who could benefit from this research
Good fit: Children and adolescents with proteinuric glomerulopathies (ongoing protein in the urine) are the intended participants.
Not a fit: Adults without pediatric proteinuric kidney disease and children who do not have proteinuria or who cannot undergo overnight monitoring or blood draws are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this work could help identify children at higher risk for cardiovascular damage so clinicians can target prevention earlier.
How similar studies have performed: Adult studies have shown that nighttime blood pressure problems predict cardiovascular harm, but combining sleep measures and transcriptomics in children is a newer and less-tested approach.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Sethna, Christine B — Feinstein Institute for Medical Research
- Study coordinator: Sethna, Christine B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.