NF1-linked glioblastoma
PROJECT 2: NF1-associated Glioblastoma
This project looks for new therapy targets for people whose glioblastoma is driven by changes in the NF1 gene.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11181020 on NIH RePORTER |
What this research studies
From a patient point of view, researchers are studying glioblastoma tumors that have NF1 gene changes to find specific weaknesses they can target. They use mouse models, patient-derived tumor grafts, lab-grown tumor cells, and real human tumor biopsies to compare tumors with germline versus somatic NF1 loss. The team also examines the tumor immune environment and tests candidate treatments first in preclinical models. Work is designed to translate findings toward therapies that could eventually be tested in patients.
Who could benefit from this research
Good fit: People with glioblastoma whose tumor tests positive for NF1 mutations or people with neurofibromatosis type 1 who develop glioblastoma.
Not a fit: Patients whose tumors do not have NF1 alterations or who have glioblastoma driven by different molecular changes are less likely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to new targeted treatments or therapy strategies for patients with NF1-associated glioblastoma.
How similar studies have performed: Preclinical studies targeting NF1-driven tumors in other organs have shown promise, but effective therapies for NF1-linked glioblastoma in humans remain unproven.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Parada, Luis Fernando — Indiana University Indianapolis
- Study coordinator: Parada, Luis Fernando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.