New ways to trigger tissue regrowth in young and aged animals
Official title: New upstream targets for HIF-1a-mediated regeneration in young and aged animals
Funded at Lankenau Institute for Medical Research · NIH-11330404 · Data updated 2026-11-12
This grant studies how to make damaged tissues regrow by triggering the body's own regenerative pathways, using a mouse model to understand how to restore jaw bone and surrounding tissues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lankenau Institute for Medical Research NIH-funded |
| Lab location | 1 site (Wynnewood, United States) |
| Project start | May 1, 2011 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $679,138 |
| NIH project number | 5R01DE021104-15 |
| Project ID | NIH-11330404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with periodontal disease or bone loss around teeth who might benefit from future regenerative therapies.
✕Less likely to help
This basic research study uses animal models and may not directly benefit patients in the short term.
What this research studies
Researchers are exploring how to reawaken natural regeneration in mammals by boosting HIF-1α signaling with injectable biomaterials. The work builds on observations that certain mouse strains can regenerate tissue, aiming to apply those insights to promote tissue healing. The project combines biology, materials science, and targeted drug delivery to see if a regenerative response can be induced in periodontal disease models. If successful, this could reveal new strategies for bone and tissue regeneration in humans.
Why it matters
Potential benefit: If this approach works, it could lead to new treatments that help people regenerate damaged bone and soft tissue in the mouth and jaw.
How similar studies have gone: Previous work in mice shows that manipulating HIF-1α pathways can drive regenerative responses in vivo.
Where this research is happening
-
Lankenau Institute for Medical Research
Wynnewood, United States Active
Researchers
- Principal investigator: Heber-Katz, Ellen S. — Lankenau Institute for Medical Research
- Study coordinator: Heber-Katz, Ellen S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.