New Ways to Help People with Alport Syndrome
Innovative Approaches to Treating Alport Syndrome
This research aims to understand how kidney damage happens in Alport syndrome to find better ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11168802 on NIH RePORTER |
What this research studies
Alport syndrome is a genetic kidney disease that can lead to kidney failure, hearing loss, and eye problems. Our kidneys have a special filter called the glomerular filtration barrier, which can become damaged and leaky in Alport syndrome. This happens because of problems with a key protein called collagen IV in the kidney's filtering membrane. We are working to understand exactly how this damage occurs at a detailed level. By learning more about these changes, we hope to discover new and effective ways to protect the kidneys and improve the lives of those with Alport syndrome.
Who could benefit from this research
Good fit: This research is relevant for anyone diagnosed with Alport syndrome or those with a family history of the condition.
Not a fit: Patients with kidney diseases not related to Alport syndrome may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or slow down kidney damage, hearing loss, and eye problems for individuals with Alport syndrome.
How similar studies have performed: While current treatments for Alport syndrome focus on managing symptoms, this research builds on existing knowledge of the disease's genetic causes to explore innovative new strategies.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Miner, Jeffrey H — Washington University
- Study coordinator: Miner, Jeffrey H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.