New radical-based methods to make complex bioactive molecules
Official title: New radical-based strategies for reaction discovery
Funded at Stanford University · NIH-11571345 · Data updated 2026-11-12
A scientist-led project at Stanford aims to develop radical-based chemical methods to build complex bioactive compounds more efficiently.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $315,627 |
| NIH project number | 7R01GM134088-07 |
| Project ID | NIH-11571345 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly patient-facing; the work is foundational chemistry that could accelerate development of treatments for various diseases.
✕Less likely to help
Patients without access to new therapies may not directly benefit from the basic chemistry advances.
What this research studies
This grant focuses on creating new radical-based reaction methods that can assemble complex, biologically active molecules. It builds on prior work using low-valent titanium to guide radical reactions in ways that are both redox-neutral or reductive and highly enantioselective. The research will explore catalyst design and reaction conditions to control where and how radicals react, even in complex molecular settings. The goal is to expand tools for chemists to access difficult chemical architectures relevant to drug discovery while prioritizing precision and selectivity.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of new drugs and more efficient synthesis of complex medicines.
How similar studies have gone: Prior work showed that radical-mediated reactions can be highly enantioselective with proper catalyst design.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Lin, Song — Stanford University
- Study coordinator: Lin, Song
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.