New methods to understand organ transplant outcomes
Methods for the Analysis of Event Processes Arising in Organ Transplantation
Builds statistical tools to help doctors and patients with end-stage kidney or liver disease see how long people live and what factors affect transplant and dialysis outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11131479 on NIH RePORTER |
What this research studies
This project creates and refines statistical methods that summarize survival and event timing for people with end-stage kidney disease (ESKD) and end-stage liver disease (ESLD). Researchers will use measures like restricted mean survival time and other event-process models on large dialysis and transplant data sets to produce clear, interpretable results. The work focuses on identifying which risk factors matter most and when events such as transplant, complications, or death tend to occur. Results are applied to real-world registry and clinical data so clinicians and patients can better weigh treatment and transplant decisions.
Who could benefit from this research
Good fit: People with end-stage kidney disease on dialysis, individuals with end-stage liver disease, transplant recipients, and patients on transplant waiting lists are the groups whose data are used and who may ultimately benefit.
Not a fit: People without kidney or liver failure or those needing immediate experimental therapies rather than better outcome information are unlikely to directly benefit from this methods-focused work.
Why it matters
Potential benefit: If successful, the methods could give clearer, easier-to-understand estimates of survival and risks after dialysis or transplant, helping inform treatment choices and organ allocation.
How similar studies have performed: Related approaches like restricted mean survival time have been used successfully in other transplant and chronic-disease studies, but this project extends and tailors those methods specifically for ESKD and ESLD.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Schaubel, Douglas Earl — University of Pennsylvania
- Study coordinator: Schaubel, Douglas Earl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.