New methods to identify cell types in Alzheimer's brains
Novel in situ proteomics methods to classify cell types in Alzheimer’s brains
This study is working on new ways to look at proteins in brain cells from people with Alzheimer's disease, using special tools to help doctors better understand the disease and find better ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10468741 on NIH RePORTER |
What this research studies
This research focuses on developing advanced techniques to analyze proteins in individual cells within preserved brain tissues, particularly those affected by Alzheimer's disease. By creating highly sensitive and multiplexed fluorescent antibodies, the project aims to improve the ability to classify different cell types in the brain. The methodology involves profiling proteins in formalin-fixed paraffin-embedded tissues, which are commonly used in clinical settings. The ultimate goal is to enhance our understanding of Alzheimer's disease and potentially improve diagnosis and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for Alzheimer's disease.
How similar studies have performed: While the approach is innovative, similar methods have shown promise in other areas of biomedical research, indicating potential for success in this context.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Guo, Jia — Arizona State University-Tempe Campus
- Study coordinator: Guo, Jia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.