New methods to find antibiotics against resistant bacteria.
Innovative technologies to transform antibiotic discovery. Project 1 Genomic applications to transform Gram-negative Antibiotic discovery
This study is looking for new ways to find antibiotics that can fight tough bacteria like Pseudomonas aeruginosa, which are becoming harder to treat, so that patients can have better options when dealing with infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10670186 on NIH RePORTER |
What this research studies
This research focuses on developing innovative strategies to discover new antibiotics, particularly targeting Gram-negative bacteria like Pseudomonas aeruginosa, which are becoming increasingly resistant to existing treatments. By combining genomic techniques with high-throughput chemical screening, the project aims to identify essential proteins in these bacteria that can be targeted by new antibiotic compounds. Patients may benefit from this research as it seeks to address the urgent need for effective antibiotics in the face of rising antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Gram-negative bacteria, particularly those that are resistant to current antibiotic treatments.
Not a fit: Patients with infections caused by Gram-positive bacteria or those who do not have bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by resistant bacteria.
How similar studies have performed: Other research has shown promise in using genomic and chemical screening approaches to discover new antibiotics, indicating that this methodology has potential for success.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Hung, Deborah T — Broad Institute, INC.
- Study coordinator: Hung, Deborah T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.