New methods to enhance interactions between biomolecules and small molecules
Official title: Bioorthogonal methods for unveiling chemical reactivity
Funded at Georgia Institute of Technology · NIH-10800059 · Data updated 2026-11-12
This study is exploring new ways to improve how medicines work in the body by creating special chemicals that can easily attach to and detach from proteins, which could lead to better drug delivery and more effective treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $317,623 |
| NIH project number | 1R01GM149693-01A1 |
| Project ID | NIH-10800059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated through enhanced drug delivery mechanisms.
✕Less likely to help
Patients with conditions that do not involve biomolecular interactions or require traditional treatment methods may not benefit from this research.
What this research studies
This research focuses on developing innovative chemical techniques that allow for precise interactions between biomolecules and small molecules within biological systems. By utilizing N-oxides, the project aims to create reversible modifications that can enhance the functionality of proteins and small molecules. The approach involves synthesizing these reagents through a rapid reaction process and controlling their attachment and release in a biological context. Patients may benefit from advancements in drug delivery and targeted therapies resulting from these new chemical methods.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted drug delivery systems for various diseases.
How similar studies have gone: Other research has shown promise in using bioorthogonal chemistry for drug delivery, indicating that this approach has potential for success.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Kim, Justin — Georgia Institute of Technology
- Study coordinator: Kim, Justin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.