New method for making CAR-T cells quickly and efficiently
Official title: MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells
Funded at Univ of North Carolina Chapel Hill · NIH-10909190 · Data updated 2026-11-12
This study is testing a new way to make CAR-T cells faster and cheaper for cancer treatment, using special tools to help speed up the process, so patients can get their therapy sooner and hopefully see better results.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2023 |
| Award (this year) | $261,931 |
| NIH project number | 7R33CA281875-02 |
| Project ID | NIH-10909190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require CAR-T cell therapy for aggressive cancers and are facing delays in treatment.
✕Less likely to help
Patients who do not require CAR-T cell therapy or those with conditions not addressed by this treatment may not benefit from this research.
What this research studies
This research focuses on improving the production of CAR-T cells, which are used in cancer treatment. The current manufacturing process is lengthy and costly, often delaying treatment for patients with aggressive diseases. The study introduces a novel technology called MASTER, which uses specialized scaffolds to streamline the CAR-T cell production process. By implanting these scaffolds with patient cells, the research aims to simplify and speed up the creation of CAR-T cells, potentially enhancing their effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to faster and more affordable CAR-T cell therapies for patients with cancer.
How similar studies have gone: While CAR-T cell therapy has shown significant success, the MASTER technology represents a novel approach that has not been widely tested in clinical settings.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Brudno, Yevgeny — Univ of North Carolina Chapel Hill
- Study coordinator: Brudno, Yevgeny
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.