New cobalt methods to make bioactive natural products
Official title: New Cobalt-mediated Methods for the Synthesis of Bioactive Triterpenoid Natural Products
Funded at Old Dominion University · NIH-11292244 · Data updated 2026-11-12
A research grant at Old Dominion University is exploring simpler, modular ways to make biologically active natural compounds that could become new medicines or agrichemicals.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $580,064 |
| NIH project number | 1R15GM163256-01 |
| Project ID | NIH-11292244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation in this project.
✕Less likely to help
This grant involves basic chemistry research with no current patient involvement.
What this research studies
Researchers will develop cobalt(III)-based catalytic methods to build key chemical motifs found in natural products. The work focuses on making synthesis shorter, cheaper, and adaptable for late-stage modification so potential lead compounds can be accessed more easily. The project aims to demonstrate how these methods enable production of biologically relevant natural products, agrochemicals, and drugs, contributing to safer and more cost-effective processes.
Why it matters
Potential benefit: If successful, the methods could speed the discovery and production of new therapies and safer agricultural chemicals.
How similar studies have gone: Previous natural product-inspired synthesis has guided drug development, supporting the potential value of this approach.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Lambert, Kyle M. — Old Dominion University
- Study coordinator: Lambert, Kyle M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.