New biodegradable stents for treating cardiovascular disease
Official title: Novel in situ custom biodegradable drug-eluting stents for endovascular surgery
Funded at VA Veterans Administration Hospital · NIH-10881772 · Data updated 2026-11-12
This study is testing a new type of stent that breaks down naturally in the body and is designed to help people with heart artery problems by improving blood flow and healing, while also lowering the chances of issues that can happen with regular metal stents.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Veterans Administration Hospital NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5I01BX004930-05 |
| Project ID | NIH-10881772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from severe atherosclerosis who require arterial stenting.
✕Less likely to help
Patients with non-atherosclerotic cardiovascular conditions or those who are not candidates for stenting may not benefit from this research.
What this research studies
This research focuses on developing a novel biodegradable stent designed to improve treatment outcomes for patients with atherosclerotic cardiovascular disease. The stent will be created using a liquid drug-eluting polymer that is photo-polymerized directly in the body, allowing it to conform to the unique shape of each artery. By delivering nitric oxide, the stent aims to enhance blood flow and promote healing while reducing the risk of complications associated with traditional metal stents. This innovative approach seeks to address the high failure rates of current stent technologies.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients with cardiovascular disease, reducing complications and improving recovery.
How similar studies have gone: While the concept of biodegradable stents is being explored, this specific approach using a custom-designed polymer and in situ formation is relatively novel and has not been widely tested.
Where this research is happening
-
VA Veterans Administration Hospital
Richmond, United States Active
Researchers
- Principal investigator: Huizar, Jose Francisco — VA Veterans Administration Hospital
- Study coordinator: Huizar, Jose Francisco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.