New anti-inflammatory treatments using synthetic galectin assemblies
Official title: Synthetic Multivalent Galectin Assemblies as Anti-Inflammatory Therapies
Funded at University of Florida · NIH-10991404 · Data updated 2026-11-12
This study is exploring a new way to help people with chronic inflammation by creating a special treatment that uses natural proteins to reduce inflammation more effectively and with fewer side effects than traditional medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | November 22, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $701,946 |
| NIH project number | 5R01AI175334-02 |
| Project ID | NIH-10991404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic inflammatory conditions who have not responded well to conventional anti-inflammatory treatments.
✕Less likely to help
Patients with acute inflammatory conditions or those who do not have chronic inflammation may not benefit from this research.
What this research studies
This research focuses on developing innovative therapies to treat chronic inflammatory conditions that affect millions of Americans. It aims to create synthetic multivalent assemblies of galectin-1 and galectin-3, which are natural regulators of inflammation, to enhance their effectiveness. By using a localized delivery method, the research seeks to minimize the side effects associated with conventional anti-inflammatory drugs. The approach involves creating a novel compound called G1/G3 Zipper, which has shown promising results in laboratory tests.
Why it matters
Potential benefit: If successful, this research could provide a more effective and safer treatment option for patients suffering from chronic inflammatory conditions.
How similar studies have gone: Previous research has shown some success with natural galectins as anti-inflammatory agents, but this approach of synthetic multivalent assemblies is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Hudalla, Gregory — University of Florida
- Study coordinator: Hudalla, Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.