Neutrophils use DNA to trap and kill pathogens
Neutrophil Extracellular Traps are Free-Radical Generating DNAzymes
['FUNDING_R21'] · STANFORD UNIVERSITY · NIH-11051171
This study is looking at how a type of immune cell called neutrophils helps fight off infections by using a special process to trap and kill germs, and it aims to understand how certain DNA structures can boost this process, which could lead to new treatments for autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11051171 on ClinicalTrials.gov |
What this research studies
This research investigates how neutrophils, a type of immune cell, utilize a process called NETosis to trap and eliminate invading pathogens. When stimulated by pathogens, neutrophils release DNA fibers that not only capture these harmful cells but also contain proteins and peptides that help kill them through oxidative stress. The study focuses on understanding the role of specific DNA structures, known as G-quadruplexes, in generating free radicals that enhance the neutrophils' bactericidal activity. By exploring these mechanisms, the research aims to uncover new insights into immune responses and potential therapeutic targets for autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions that involve dysregulated immune responses.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune system dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by enhancing our understanding of immune cell functions.
How similar studies have performed: Other research has shown promise in understanding immune cell mechanisms, but this specific approach focusing on G-quadruplexes is relatively novel.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, SAMUEL — STANFORD UNIVERSITY
- Study coordinator: YANG, SAMUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease