NIH-funded research NIH-funded research

Neuromusculoskeletal Interface to Control a Bionic Arm

Official title: A Neuromusculoskeletal Interface for Bionic Arms: A Randomized Crossover Study

Funded at Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · NIH-11380708 · Data updated 2026-11-12

A cutting-edge, socket-free prosthesis that uses bone-anchored implants and muscle signals to control movements, helping people with arm loss regain natural use of their artificial arm.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionRehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
NIH-funded
Lab location1 site (Chicago, United States)
Project startJune 1, 2023
Project endJuly 31, 2029
Funding year2026
Award (this year)$2,168,982
NIH project number5UH3NS127063-03
Project IDNIH-11380708 on NIH RePORTER

Who could benefit from this research

Could help

Adults with upper-limb amputation who are candidates for osseointegrated prosthetic attachment and EMG-based control.

Less likely to help

Individuals who are not eligible for osseointegration or who have contraindications to surgery or EMG-based control may not benefit.

What this research studies

This project aims to improve how people with arm loss connect their body to a prosthetic arm by attaching the prosthesis directly to the bone and decoding muscle signals to drive movement. It combines osseointegration, a bone-anchored implant, with advanced computer algorithms that translate EMG signals into precise prosthetic actions. The study uses a randomized crossover design to compare control methods and assess user experience, durability, and function over time. Participants living with an upper-limb amputation could potentially experience greater comfort, control, and natural-feeling use of their prosthesis.

Why it matters

Potential benefit: If successful, this approach could offer more natural, reliable control of an artificial arm and reduce socket-related skin problems for many users.

How similar studies have gone: Previous work shows promise with bone-anchored prostheses and EMG decoding, but randomized crossover data in this area remains evolving.

Where this research is happening

  • Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
    Chicago, United States
    Active

Researchers

  • Principal investigator: Hargrove, Levi John — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
  • Study coordinator: Hargrove, Levi John

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About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.