Neddylation and blood vessel health in adults
Official title: Regulation of endothelial function and vascular integrity by neddylation
Funded at University of Nebraska Lincoln · NIH-11403834 · Data updated 2026-11-12
Aims to understand how a tiny cellular switch called neddylation keeps blood vessels healthy and what goes wrong in vascular disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $670,524 |
| NIH project number | 5R01HL175569-02 |
| Project ID | NIH-11403834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with vascular conditions or those at risk who may benefit from therapies targeting endothelial cell health.
✕Less likely to help
Healthy individuals without vascular disease may not directly benefit.
What this research studies
This research examines how the protein modification process neddylation affects endothelial cells that line our blood vessels, using adult models to uncover mechanisms behind vascular disease. The team will study how neddylation controls endothelial identity, cell survival, and mitophagy, and how disrupting this process leads to vessel damage. By identifying key downstream targets like CUL3, they hope to map pathways that maintain vascular integrity and prevent hemorrhage in disease contexts. The work builds on prior findings in mice showing that blocking neddylation in endothelial cells causes vasculopathy and organ damage. The project aims to translate these insights toward protecting blood vessel health in humans.
Why it matters
Potential benefit: If successful, findings could reveal new targets to preserve or restore blood vessel integrity in vascular diseases.
How similar studies have gone: Previous work in mice suggests that endothelial neddylation is essential for vessel integrity, supporting potential relevance in humans.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Sun, Xinghui — University of Nebraska Lincoln
- Study coordinator: Sun, Xinghui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.