Natriuretic peptide clearance receptor and heart failure with preserved ejection fraction
Official title: A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.
Funded at Veterans Health Administration · NIH-11398691 · Data updated 2026-11-12
A study exploring a potential new target to help people with HFpEF, aiming to improve heart function and energy use in the heart.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2023 |
| Project end | March 30, 2028 |
| Funding year | 2026 |
| NIH project number | 5IK2BX005828-04 |
| Project ID | NIH-11398691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HFpEF or at risk of HFpEF, particularly those with obesity/metabolic dysfunction, may benefit from future therapies emerging from this work.
✕Less likely to help
Early-stage research may not yield immediate clinical benefits for current patients.
What this research studies
This project focuses on understanding how the natriuretic peptide clearance receptor may affect heart failure with preserved ejection fraction (HFpEF), especially in patients who also have obesity or metabolic dysfunction. The research will involve training a clinician-scientist to pursue this line of investigation under seasoned mentors, with an emphasis on mechanisms in heart muscle and energy metabolism. The goal is to identify therapies that could restore proper energy use in the failing heart and improve patient outcomes. The work is grounded in translational research that could eventually lead to new treatment strategies for HFpEF patients.
Why it matters
Potential benefit: If successful, the research could reveal new targets to treat HFpEF and improve survival and quality of life for patients, especially those with obesity-related metabolic issues.
How similar studies have gone: Previous work suggests targeting energy metabolism and mitochondrial function can influence HFpEF outcomes, but direct therapies remain to be proven.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Agrawal, Vineet — Veterans Health Administration
- Study coordinator: Agrawal, Vineet
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.