Native Mass Spectrometry Center for Protein Complexes
Official title: Native Mass Spectrometry Guided Structural Biology Center
Funded at Georgia Institute of Technology · NIH-11401977 · Data updated 2026-11-12
A center will develop and share powerful mass spectrometry-based tools to study how protein complexes assemble and change under different conditions, with the goal of advancing understanding of diseases linked to AIDS virus and related cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 19, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,171,419 |
| NIH project number | 5RM1GM149374-04 |
| Project ID | NIH-11401977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group; disease-relevant protein studies may inform future therapies for AIDS-related cancers and other conditions.
✕Less likely to help
There is no direct patient participation in this center during the grant period.
What this research studies
This project aims to transform an existing mass spectrometry resource into a center that makes advanced technology widely available for analyzing how protein machines assemble, their parts, and how they change shape or interactions. It will run three integrated technology development projects, building on prior work and collaborations with instrument vendors and industry partners. The center will provide workflows that integrate native mass spectrometry with other structural biology methods to reveal detailed pictures of protein complexes relevant to AIDS and cancer biology. Researchers and industry partners will collaborate to ensure the tools are robust, user-friendly, and broadly disseminated. The effort will include validation studies and training to help other labs adopt these methods.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more accurate insights into how disease-related proteins assemble and respond to treatments.
How similar studies have gone: Previous work has produced commercially licensed tools and demonstrated feasibility, with ongoing expansion and adoption by the research community.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Wysocki, Vicki H. — Georgia Institute of Technology
- Study coordinator: Wysocki, Vicki H.
Related research
Other NIH-funded projects on the same topics.
-
Integrative AI tools to map protein sequences to structures and functions
A scientist team will develop advanced AI methods to better connect protein sequences, their 3D shapes, and how they work, using large biological data from sequencing and structures.
-
Robotic ultrasound-guided clot removal for stroke treatment
A new robot-assisted ultrasound system is being developed to help quickly reopen brain arteries during a stroke, with testing in patient-specific 3D-printed models and animal studies.
-
siRNA nanoparticle treatment to stop diabetic kidney damage
A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.
-
Nanosensor blood test to spot early pancreatic cancer fingerprints
This project will use a nanosensor blood test to detect early-stage pancreatic cancer by reading a disease 'fingerprint' in patient serum.
-
Synergistic blood-brain barrier opening and targeted glioma treatment with pulsed electric fields
A new approach uses tiny, rapid electric pulses to safely disrupt the brain's protective barrier and enhance targeted treatment for malignant glioma.
-
Dexterous needle ablation for ventricular arrhythmia guided by MRI
A new MRI-guided, robot-assisted catheter delivers deeper heart tissue ablation to treat ventricular tachycardia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.