Nanogel-enabled Glycosylation Analysis at the Nanoscale
Official title: Nanogel Electrophoresis for Micro and Nanoscale Analyses of Glycosylation
Funded at West Virginia University · NIH-11349672 · Data updated 2026-11-12
Aims to develop tiny, biocompatible nanogel methods to study glycosylation patterns, especially sialylation, in biochemical samples using advanced capillary electrophoresis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $382,500 |
| NIH project number | 5R35GM158188-02 |
| Project ID | NIH-11349672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals or samples with interest in glycosylation biology, biomarker development, or diseases where glycan changes are informative.
✕Less likely to help
People without access to biological samples or interest in glycan analysis may not directly benefit.
What this research studies
This project from West Virginia University adapts self-assembled nanogels to perform ultra-small, real-time enzymatic reactions within capillary electrophoresis workflows. By keeping biomolecules functional while creating nanoliter reaction zones, the approach allows rapid, low-volume measurements of enzyme activity under physiological conditions. The work combines miniature biochemistry with novel separation techniques to better distinguish similar glycan structures and their linkages, which are important for health and disease. If successful, these methods could enable more precise biomarker analysis and drug target exploration related to glycosylation.
Why it matters
Potential benefit: Patients could benefit from faster, more sensitive tests for glycosylation-related biomarkers and drug targets.
How similar studies have gone: Previous work shows that nanogel-based separations can enable nanoscale reactions and rapid analyses, supporting potential success.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Holland, Lisa a — West Virginia University
- Study coordinator: Holland, Lisa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.