Muscarinic receptors influence colon cancer stem cells and their spread
Muscarinic Receptors Regulate Colon Cancer Stem Cell Function and Invasiveness
This study is looking at how certain receptors in colon cancer cells might influence their growth and ability to spread, with the goal of finding new ways to treat colon cancer more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10881726 on NIH RePORTER |
What this research studies
This research investigates how specific muscarinic receptors, particularly M1R and M3R, affect the behavior of colon cancer stem cells and their ability to spread in the body. By understanding the roles of these receptors in colon cancer progression, the research aims to identify new treatment strategies that could more effectively target and inhibit cancer growth and metastasis. The study will involve laboratory experiments to analyze the expression of these receptors in colon cancer cells and their impact on cancer resilience and response to therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with advanced colon cancer who are seeking new treatment options.
Not a fit: Patients with early-stage colon cancer or those not diagnosed with colon cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colon cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in targeting muscarinic receptors in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
Baltimore, United States
- Baltimore VA Medical Center — Baltimore, United States (Active)
Researchers
- Principal investigator: Raufman, Jean-Pierre — Baltimore VA Medical Center
- Study coordinator: Raufman, Jean-Pierre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.