Multi-omic tool to reveal how drugs work
Official title: eMOA: A Multi-Omic Service for Mechanism of Action Determination in Drug Screening
Funded at Eclipse Bioinnovations INC · NIH-11258908 · Data updated 2026-11-12
A new software-enabled service helps scientists quickly figure out exactly how potential drugs work on human biology using multiple biological readouts.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Eclipse Bioinnovations INC NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $823,650 |
| NIH project number | 5R44GM154583-03 |
| Project ID | NIH-11258908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing trial; results may accelerate development of therapies that eventually benefit patients.
✕Less likely to help
Direct participation by patients is not part of this grant.
What this research studies
This project develops a service that integrates multiple omics data to determine how drug candidates exert their effects. It aims to speed up drug discovery by clarifying mechanisms of action earlier in the screening process. The work will be conducted by Eclipse BioInnovations in San Diego and involves collaboration with researchers to test in vitro systems and translate findings toward human biology. If successful, it could reduce costly late-stage failures by giving clearer insights into how compounds act at the molecular level.
Why it matters
Potential benefit: Could help identify safer and more effective drug candidates sooner, potentially shortening time to clinical testing.
How similar studies have gone: Omics-based approaches have shown promise in clarifying drug mechanisms, with growing adoption in early drug discovery.
Where this research is happening
-
Eclipse Bioinnovations INC
San Diego, United States Active
Researchers
- Principal investigator: Shishkin, Alexander a — Eclipse Bioinnovations INC
- Study coordinator: Shishkin, Alexander a
Related research
Other NIH-funded projects on the same topics.
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A service to determine how drugs work at a molecular level
This study is working on a new way to understand how drugs work in our cells, which could help make drug development quicker and cheaper, ultimately leading to better treatments for patients like you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.