Mucus-loving gut bacteria and gut toxicity after stem cell transplant
Official title: Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation
Funded at Beckman Research Institute/city of Hope · NIH-11417311 · Data updated 2026-11-12
This grant studies how gut bacteria that eat mucus influence toxicities after hematopoietic cell transplantation and what can be done to keep patients safer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,364,370 |
| NIH project number | 5P01HL170046-03 |
| Project ID | NIH-11417311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing allogeneic hematopoietic cell transplantation and their caregivers in the transplant setting.
✕Less likely to help
Patients not undergoing transplant or not affected by gut toxicity related to transplant are unlikely to benefit.
What this research studies
This program looks at the gut microbiome in people undergoing allogeneic hematopoietic cell transplantation and how mucus-degrading bacteria may worsen transplant-related complications. Researchers will use animal and human data to understand how mucus-utilizing bacteria interact with antibiotics and conditioning regimens to affect the gut lining and immune responses. The work aims to identify mechanisms and potential interventions to protect the intestinal barrier and reduce graft-versus-host disease and fevers. Results could guide better antibiotic use and microbiome-targeted therapies for transplant patients.
Why it matters
Potential benefit: Better understanding of gut bacteria roles could lead to strategies that reduce gut-related toxicities and improve recovery after stem cell transplantation.
How similar studies have gone: Previous work suggests mucin-utilizing bacteria impact gut health under antibiotic treatment; this proposal expands on that with integrated projects.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Jenq, Robert — Beckman Research Institute/city of Hope
- Study coordinator: Jenq, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.