Mucosal regulatory T cells help shape memory T cell responses
Official title: Mucosal regulatory T cells modulate the recalled memory T cell response
Funded at Fred Hutchinson Cancer Center · NIH-11446847 · Data updated 2026-11-12
A project exploring how tissue-regulating T cells influence memory T cells to protect against infections while keeping tissues safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $879,998 |
| NIH project number | 1R01AI194451-01A1 |
| Project ID | NIH-11446847 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with mucosal infections or immune conditions where tissue-resident memory and regulatory T cells play a role could potentially benefit in the long term.
✕Less likely to help
Individuals without mucosal infection or immune-related tissue damage may not directly benefit from this basic mechanistic work.
What this research studies
This study looks at tissue resident memory T cells and asks how regulatory T cells control their recall responses during re-infection. Researchers will examine how Tregs enter, stay in, and regulate these tissues to balance protection with preventing damage. The work will use human-relevant systems and tissue samples to map signals guiding Treg function in mucosal sites. Outcomes may reveal targets to fine-tune immune memory without causing tissue injury.
Why it matters
Potential benefit: Understanding this regulation could lead to therapies that boost protective memory responses while reducing immune-mediated tissue damage during infections.
How similar studies have gone: Prior work suggests tissue regulatory T cells influence local immune responses, but the precise role in memory recall is not fully defined and remains a promising area.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Lund, Jennifer M — Fred Hutchinson Cancer Center
- Study coordinator: Lund, Jennifer M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.