Monitoring T-cell responses to specific antigens in real-time
Dynamic, live-cell monitoring of T-cell states against presented peptides
['FUNDING_SBIR_1'] · PUMPKINSEED TECHNOLOGIES INC · NIH-11186158
This study is testing a new technology that helps scientists watch how T cells, which are important for our immune system, react to different substances, with the goal of finding better treatments for people with autoimmune diseases and cancer.
Quick facts
| Phase | ['FUNDING_SBIR_1'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PUMPKINSEED TECHNOLOGIES INC (nih funded) |
| Locations | 1 site (PALO ALTO, UNITED STATES) |
| Trial ID | NIH-11186158 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new technology called cell-MAPP, which allows for real-time monitoring of T cells as they respond to different antigens. By using advanced techniques like antigen-multimer barcoding and T-cell receptor sequencing, the researchers aim to track the behavior and state changes of individual T cells during stimulation. This could provide valuable insights into how T cells interact with potential vaccine candidates and improve personalized cancer therapies. The technology is designed to enhance our understanding of immune responses, which could lead to better treatment options for patients with autoimmune diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with autoimmune diseases or cancer who may benefit from advanced T-cell therapies.
Not a fit: Patients who do not have autoimmune conditions or cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective T-cell therapies and personalized vaccines for patients.
How similar studies have performed: Other research has shown promise in using advanced monitoring techniques for immune cells, suggesting that this approach could yield significant insights.
Where this research is happening
PALO ALTO, UNITED STATES
- PUMPKINSEED TECHNOLOGIES INC — PALO ALTO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, JACK — PUMPKINSEED TECHNOLOGIES INC
- Study coordinator: HU, JACK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder