Monitoring T-cell responses to specific antigens in real-time
Official title: Dynamic, live-cell monitoring of T-cell states against presented peptides
Funded at Pumpkinseed Technologies INC · NIH-11186158 · Data updated 2026-11-12
This study is testing a new technology that helps scientists watch how T cells, which are important for our immune system, react to different substances, with the goal of finding better treatments for people with autoimmune diseases and cancer.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pumpkinseed Technologies INC NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | June 19, 2025 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $353,204 |
| NIH project number | 1R43CA302286-01 |
| Project ID | NIH-11186158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with autoimmune diseases or cancer who may benefit from advanced T-cell therapies.
✕Less likely to help
Patients who do not have autoimmune conditions or cancer may not receive direct benefits from this research.
What this research studies
This research focuses on developing a new technology called cell-MAPP, which allows for real-time monitoring of T cells as they respond to different antigens. By using advanced techniques like antigen-multimer barcoding and T-cell receptor sequencing, the researchers aim to track the behavior and state changes of individual T cells during stimulation. This could provide valuable insights into how T cells interact with potential vaccine candidates and improve personalized cancer therapies. The technology is designed to enhance our understanding of immune responses, which could lead to better treatment options for patients with autoimmune diseases and cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective T-cell therapies and personalized vaccines for patients.
How similar studies have gone: Other research has shown promise in using advanced monitoring techniques for immune cells, suggesting that this approach could yield significant insights.
Where this research is happening
-
Pumpkinseed Technologies INC
Palo Alto, United States Active
Researchers
- Principal investigator: Hu, Jack — Pumpkinseed Technologies INC
- Study coordinator: Hu, Jack
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.