Monitoring cancer treatment response using exosomes in lung cancer patients
Official title: Noninvasive monitoring of therapeutic response to immune checkpoint inhibitors using circulating exosomes in non-small cell lung cancer
Funded at University of Miami School of Medicine · NIH-10890842 · Data updated 2026-11-12
This study is looking at how tiny particles in your blood, called exosomes, can help doctors see how well certain cancer treatments are working for people with non-small cell lung cancer, so they can better tailor the treatment to each patient without needing to do any painful procedures.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $204,520 |
| NIH project number | 5R21CA283881-02 |
| Project ID | NIH-10890842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced non-small cell lung cancer who are receiving immune checkpoint inhibitor therapy.
✕Less likely to help
Patients with early-stage lung cancer or those not undergoing immune checkpoint inhibitor therapy may not benefit from this research.
What this research studies
This research investigates how circulating exosomes can be used to monitor the effectiveness of immune checkpoint inhibitors in patients with non-small cell lung cancer (NSCLC). By isolating and analyzing specific exosomes related to the immune response, the study aims to predict which patients will benefit from treatment and to track their response in real-time. This noninvasive approach could provide valuable insights into treatment efficacy without the need for invasive biopsies. The goal is to enhance personalized treatment strategies for lung cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment plans for lung cancer patients, improving their chances of survival.
How similar studies have gone: Previous research has shown promise in using exosomes as biomarkers for cancer treatment response, indicating that this approach may be viable.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Daunert, Sylvia — University of Miami School of Medicine
- Study coordinator: Daunert, Sylvia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.