Molecular profiling to understand lupus effects on skin and kidneys
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
This project uses advanced molecular tests on skin, kidney, blood, and urine from people with lupus to find biological patterns that explain differences in disease and treatment responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11307666 on NIH RePORTER |
What this research studies
You would be asked to give skin or kidney tissue, blood, and urine so researchers can run genome and protein tests that show what’s happening at a molecular level. The team will compare very early kidney disease to established kidney disease and look at different types of skin lupus to understand why symptoms and treatment responses vary. They will use transcriptomic and proteomic methods and share high-quality samples with other researchers to speed discovery. The goal is to link molecular patterns to real symptoms and treatment results so care can become more personalized.
Who could benefit from this research
Good fit: People with systemic lupus erythematosus who have active or suspected lupus nephritis or cutaneous lupus and who can provide biopsy tissue, blood, or urine are the ideal candidates.
Not a fit: People without lupus, those whose disease affects only other organs, or those unable or unwilling to provide tissue samples are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, this work could help doctors detect lupus kidney disease earlier and pick treatments that are more likely to work for each person.
How similar studies have performed: This builds on AMP1 efforts that produced high-quality tissue and molecular data, and similar multi-omics approaches have revealed important biological insights though full clinical translation is still ongoing.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Buyon, Jill P — New York University School of Medicine
- Study coordinator: Buyon, Jill P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.