Modeling how brain stimulation helps depression in Veterans

Who could benefit from this research

What this research studies

This project looks at why some Veterans respond differently to TMS treatment for major depressive disorder and seeks ways to optimize how TMS is delivered. It will use clinical data from Veterans to identify patterns that predict better responses and explore cost-effective approaches to improve outcomes. The effort emphasizes practical, bedside applications and could lead to more personalized TMS care in real-world clinics. The study is centered at Providence VA Medical Center, with patient data guiding improvements to TMS protocols and integration with measurement-based care.

Why it matters

Where this research is happening

• Providence VA Medical Center
  Providence, United States Active

Researchers

• Principal investigator: Berlow, Yosef Alfred — Providence VA Medical Center
• Study coordinator: Berlow, Yosef Alfred

Related research

Other NIH-funded projects on the same topics.

• Understanding how rTMS may reduce brain inflammation in depression and related brain conditions

  This study tests whether a noninvasive brain stimulation (rTMS) changes brain inflammation in people with depression and certain brain conditions.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11284181

• Using magnetic stimulation to improve brain barrier function in depression treatment

  This study is looking at how a treatment called transcranial magnetic stimulation (TMS) might help improve the protective barrier in the brain for people with treatment-resistant depression, to see if fixing this barrier can lead to feeling better.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11089533

• Combining brain stimulation and therapy to help veterans with chronic pain and depression

  This study is exploring a new way to help veterans who are dealing with both chronic pain and depression by using a combination of brain stimulation and therapy to improve their pain and mood.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11071939

• Understanding how Transcranial Magnetic Stimulation helps treat depression in Veterans

  This study is looking at how well Transcranial Magnetic Stimulation (TMS) can help Veterans with Major Depressive Disorder who haven't found relief from regular medications, aiming to find the best ways to make this treatment work better for everyone.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11043390

• Biotype-based Personalization of Antidepressant Augmentation in Late-Life Depression

  A multi-site study will test a computer-guided approach to choosing the best augmentation option for older adults with treatment-resistant depression.

  NIH research Washington University · Saint Louis, United States · NIH-11625616

• Suubi-Mhealth: a mobile app to help Ugandan youth with HIV manage depression and ART adherence

  A mobile app designed for 14–17 year olds in Uganda aims to support mental health and keep HIV treatment on track.

  NIH research Washington University · Saint Louis, United States · NIH-11614513

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.