Modeling cancer mutations at the single cell level
Single cell modeling of cancer mutations
This study is exploring how specific cancer mutations change the behavior of cancer cells by using a new technology that lets scientists introduce these mutations into individual cells and see how they affect gene activity, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11088750 on NIH RePORTER |
What this research studies
This research investigates the biological effects of cancer mutations by developing a novel technology called transcript-informed single cell CRISPR sequencing (TISCC-seq). It combines CRISPR engineering to introduce specific cancer mutations into individual cells with single-cell RNA sequencing to analyze the resulting gene expression. By using this approach, researchers aim to create detailed experimental models that can reveal how these mutations affect cancer biology. This could lead to a better understanding of cancer mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with specific cancer types that exhibit known mutations.
Not a fit: Patients without identifiable cancer mutations or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the functional consequences of cancer mutations, potentially leading to more effective treatments.
How similar studies have performed: Other research has shown promise in using CRISPR and single-cell sequencing technologies to study cancer, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Ji, Hanlee P — Stanford University
- Study coordinator: Ji, Hanlee P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.