Modeling cancer mutations at the single cell level
Official title: Single cell modeling of cancer mutations
Funded at Stanford University · NIH-11088750 · Data updated 2026-11-12
This study is exploring how specific cancer mutations change the behavior of cancer cells by using a new technology that lets scientists introduce these mutations into individual cells and see how they affect gene activity, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $382,134 |
| NIH project number | 5R33CA278469-03 |
| Project ID | NIH-11088750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with specific cancer types that exhibit known mutations.
✕Less likely to help
Patients without identifiable cancer mutations or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research investigates the biological effects of cancer mutations by developing a novel technology called transcript-informed single cell CRISPR sequencing (TISCC-seq). It combines CRISPR engineering to introduce specific cancer mutations into individual cells with single-cell RNA sequencing to analyze the resulting gene expression. By using this approach, researchers aim to create detailed experimental models that can reveal how these mutations affect cancer biology. This could lead to a better understanding of cancer mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the functional consequences of cancer mutations, potentially leading to more effective treatments.
How similar studies have gone: Other research has shown promise in using CRISPR and single-cell sequencing technologies to study cancer, indicating that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Ji, Hanlee P — Stanford University
- Study coordinator: Ji, Hanlee P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.