Metabolic factors in pediatric mitochondrial disorders and organ dysfunction
Official title: Metabolic regulation of MODS in pediatric mitochondrial disorders
Funded at University of Arkansas at Fayetteville · NIH-11326308 · Data updated 2026-11-12
This project looks at why kids with mitochondrial disorders develop multi-organ problems by studying how energy metabolism and specific molecules affect cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $606,257 |
| NIH project number | 5R01HD110536-04 |
| Project ID | NIH-11326308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with diagnosed pediatric mitochondrial disorders and healthy age-matched controls (as comparison).
✕Less likely to help
Children without mitochondrial disorders or those not matching the study’s inclusion criteria may not benefit.
What this research studies
Researchers will study skin cells from children with mitochondrial diseases to map how mitochondria malfunction across tissues. They will use stem-cell techniques, sequencing, and metabolite profiling to explore the links between bioenergetics, oxidative stress, and organ damage. The goal is to identify key pathways that drive multi-organ failure so future treatments can target them. The work builds on prior findings of altered metabolism and mitochondrial morphology in patient cells.
Why it matters
Potential benefit: If successful, findings could lead to targeted therapies that protect organs in children with mitochondrial disorders.
How similar studies have gone: Previous cellular studies have linked mitochondrial dysfunction to organ impairment, with emerging but still limited actionable targets.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Iyer, Shilpa — University of Arkansas at Fayetteville
- Study coordinator: Iyer, Shilpa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.