Mechanistic insights into how a DNA damage bypass enzyme influences genome stability
Official title: Mechanistic insights into translesion synthesis-dependent genome instability
Funded at University of Vermont & St Agric College · NIH-11380789 · Data updated 2026-11-12
This NIH grant studies how the REV1 enzyme, involved in bypassing DNA damage, affects genome stability and cell fate with potential links to cancer and infectious diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $378,240 |
| NIH project number | 5R35GM150992-04 |
| Project ID | NIH-11380789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participants in this project (basic science emphasis in cell and molecular studies).
✕Less likely to help
No direct patient participation is anticipated in this basic science grant.
What this research studies
The research looks at how the REV1 polymerase contributes to genome instability beyond its known role in bypassing DNA damage. By studying cellular processes like autophagy, metabolism, mitosis, and rereplication, the project aims to understand how REV1 influences cell death decisions after DNA damage. The team plans to use molecular and cellular approaches to uncover how REV1 shapes autophagy versus senescence and how these pathways affect disease-related changes in cells. Findings could point toward new therapeutic strategies that target genome instability in human diseases.
Why it matters
Potential benefit: If successful, this work could lead to new approaches to treat cancers and infectious diseases by manipulating REV1-related pathways to reduce harmful genome changes.
How similar studies have gone: Previous work shows REV1 influences genome stability, with emerging but evolving evidence suggesting broader roles in cell regulation.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Chatterjee, Nimrat — University of Vermont & St Agric College
- Study coordinator: Chatterjee, Nimrat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.