Measuring proteins in blood to improve personalized medicine for children with type 1 diabetes
Official title: Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetes
Funded at University of Washington · NIH-10891722 · Data updated 2026-11-12
This study is working on better blood tests to help doctors find the right treatments for kids with type 1 diabetes by measuring important proteins, which could lead to improved care and management of the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 21, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $848,497 |
| NIH project number | 5U01DK137097-02 |
| Project ID | NIH-10891722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with type 1 diabetes.
✕Less likely to help
Patients with type 1 diabetes who are older than 11 years may not benefit directly from this research.
What this research studies
This research focuses on developing advanced blood tests to measure proteins that can help personalize treatment for children with type 1 diabetes. By using a technique called liquid chromatography-tandem mass spectrometry, the researchers aim to create more accurate and sensitive assays for detecting important biomarkers. This could lead to better predictions and management of the disease, ultimately improving patient care. The study will also explore new methods to enhance the sensitivity of these tests, making them more effective for clinical use.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for children with type 1 diabetes.
How similar studies have gone: Previous research using mass spectrometry for biomarker detection has shown promising results, indicating that this approach could be effective.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Hoofnagle, Andrew N — University of Washington
- Study coordinator: Hoofnagle, Andrew N
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.