Mapping the small blood vessel network in the brain affected by type 2 diabetes
Longitudinal Imaging of Cortical Small Vessel Network Structure with Two-Color Multiphoton Fluorescence Microscopy
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10445002
This study is looking at how type 2 diabetes affects the tiny blood vessels in the brain, which are important for keeping our brains healthy, by using special imaging techniques on mice to create detailed maps of these vessels over time, helping us learn more about how diabetes might impact brain function and health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10445002 on ClinicalTrials.gov |
What this research studies
This research investigates how type 2 diabetes affects the small blood vessels in the brain, which are crucial for brain health. Using advanced imaging techniques, the study aims to create detailed three-dimensional maps of these microvascular networks in living mice. By observing these changes over time, researchers hope to better understand the impact of diabetes on brain function and structure. This work could lead to new insights into the relationship between diabetes and brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who may be experiencing cognitive or neurological symptoms.
Not a fit: Patients without type 2 diabetes or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve our understanding of how type 2 diabetes affects brain health, potentially leading to better treatments for related brain disorders.
How similar studies have performed: While there has been research on diabetes effects in peripheral organs, this specific approach to mapping cerebral microvasculature in vivo is novel and has not been extensively tested.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUNN, ANDREW K — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: DUNN, ANDREW K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Encephalon Diseases