Mapping the genes and epigenetics of human salivary glands
Official title: High resolution genomic and epigenomic mapping of the human salivary gland
Funded at State University of New York at Buffalo · NIH-10727190 · Data updated 2026-11-12
This study is looking at how different cells in our salivary glands work together and how their health can be affected, with the goal of finding better treatments for conditions like Sjogren syndrome and issues related to cancer, using advanced techniques to understand these cells better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $440,973 |
| NIH project number | 1R21DE033156-01 |
| Project ID | NIH-10727190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with autoimmune diseases affecting the salivary glands, such as Sjogren syndrome, or those undergoing treatment for head and neck cancers.
✕Less likely to help
Patients with conditions unrelated to salivary gland function or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the complex biology of human salivary glands, focusing on how different cell types within these glands interact and function. By examining the genetic and epigenetic factors that influence salivary gland health, the study aims to uncover mechanisms that could lead to better treatments for conditions like Sjogren syndrome and cancer-related complications. The approach involves advanced techniques such as single-cell RNA sequencing to analyze the gene activity of individual cells in the salivary glands. This detailed understanding could help identify new therapeutic targets for diseases affecting these glands.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and cancers that impact salivary gland function.
How similar studies have gone: While the specific focus on salivary glands is less explored, similar genomic and epigenomic mapping studies have shown promise in understanding other tissues and diseases.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Sinha, Satrajit — State University of New York at Buffalo
- Study coordinator: Sinha, Satrajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.