Mapping the complex structure of the brain in three dimensions
Official title: Exa-scale tissue readout methods
Funded at Allen Institute · NIH-10909733 · Data updated 2026-11-12
This study is working on new ways to make detailed 3D maps of the brain to help us understand how brain cells talk to each other, which could lead to better ways to diagnose and treat neurological diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2024 |
| Project end | September 18, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,271,280 |
| NIH project number | 1DP2MH140592-01 |
| Project ID | NIH-10909733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or those interested in the biological mechanisms of brain function.
✕Less likely to help
Patients with conditions unrelated to neurological function or those not residing in the research area may not benefit from this research.
What this research studies
This research focuses on developing advanced methods to create detailed three-dimensional maps of the brain, which are essential for understanding how neurons communicate and function. By utilizing innovative techniques such as tissue expansion, multiplexed antibody labeling, and in situ sequencing, the project aims to visualize numerous molecular markers within brain tissue. This comprehensive approach will help researchers gain insights into brain function and the underlying mechanisms of neurological diseases, ultimately improving diagnostic and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in diagnosing and treating neurological disorders by providing a clearer understanding of brain structure and function.
How similar studies have gone: Previous research has shown promise in similar approaches, indicating potential for significant advancements in neuroscience.
Where this research is happening
-
Allen Institute
Seattle, United States Active
Researchers
- Principal investigator: Glaser, Adam K — Allen Institute
- Study coordinator: Glaser, Adam K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.