Mapping human brain circuitry using advanced imaging techniques
Official title: Mapping Human Neurocircuitry Across Scales with Diffusion MRI and Optical Imaging
Funded at Massachusetts General Hospital · NIH-11073105 · Data updated 2026-11-12
This study is working on creating clearer pictures of the brain's wiring to help us understand how it works and what goes wrong in brain disorders, which could lead to better ways to diagnose and treat patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $576,339 |
| NIH project number | 5R01NS127353-06 |
| Project ID | NIH-11073105 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or those interested in brain health and imaging advancements.
✕Less likely to help
Patients with conditions unrelated to brain circuitry or those not requiring advanced imaging techniques may not benefit from this research.
What this research studies
This research aims to create detailed images of human brain white-matter circuitry by utilizing advanced technologies such as diffusion MRI and optical imaging. The project will analyze brain samples to improve the accuracy of algorithms that reconstruct brain circuitry from imaging data. By combining microscopic and mesoscopic imaging techniques, the researchers hope to gain insights into the complex architecture of brain pathways, which could lead to better understanding of brain function and disorders. Patients may benefit from improved diagnostic tools and treatment strategies based on enhanced brain imaging techniques.
Why it matters
Potential benefit: If successful, this research could lead to more accurate brain imaging techniques that improve diagnosis and treatment of neurological conditions.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to map brain circuitry, suggesting that this approach could yield significant insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Yendiki, Anastasia — Massachusetts General Hospital
- Study coordinator: Yendiki, Anastasia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.