Mapping how proteins interact with chromatin structures in cells
Official title: Mapping protein signatures to single allele chromatin topologies at genomic resolution
Funded at University of Illinois at Chicago · NIH-10824336 · Data updated 2026-11-12
This study is looking at how proteins interact with DNA in our cells to help us understand how genes are turned on and off, which could give us clues about how different cells work and what might go wrong in diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | April 7, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $174,346 |
| NIH project number | 5R21CA282715-02 |
| Project ID | NIH-10824336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by chromatin structure and gene expression.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or gene regulation may not benefit from this research.
What this research studies
This research investigates the organization of chromatin in cells, focusing on how proteins bind to specific regions of DNA and influence gene expression. By utilizing advanced imaging techniques, the researchers aim to visualize and map the interactions between proteins and chromatin at a very detailed level. This approach will help to understand the variability in chromatin structures among individual cells, which is crucial for deciphering the complexities of gene regulation. The study will involve characterizing the relationship between chromatin topology and protein coverage, providing insights into cellular function and potential disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic targets for diseases linked to chromatin dysfunction.
How similar studies have gone: Other research has shown promising results using advanced imaging techniques to study chromatin dynamics, indicating that this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Spille, Jan-Hendrik — University of Illinois at Chicago
- Study coordinator: Spille, Jan-Hendrik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.