Mapping how Ig-fold membrane proteins talk to their partners with nanobody tools
Official title: Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based Tools
Funded at Icahn School of Medicine at Mount Sinai · NIH-11529125 · Data updated 2026-11-12
This grant supports building a high-precision tool to map how immune-related membrane proteins communicate with their partners in living cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 10, 2020 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $249,391 |
| NIH project number | 3R35GM137905-06S1 |
| Project ID | NIH-11529125 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient population; research focuses on cellular interactions and proteomics relevant to disease biology.
✕Less likely to help
Direct patient benefits may be limited to long-term translational insights rather than immediate treatments.
What this research studies
The project aims to develop a nanobody-based proximity proteomics platform to reveal the dynamic interaction networks of Ig-fold membrane proteins. It plans to leverage a CyBio SPR instrument to measure interactions under physiological conditions, enabling high-resolution maps of protein networks. This could help identify how immune-related membrane proteins drive signaling in health and disease. The work is conducted at Icahn School of Medicine at Mount Sinai in New York, led by Yi Shi.
Why it matters
Potential benefit: If successful, patients could benefit from a better understanding of membrane protein signaling that underpins immune responses and disease processes.
How similar studies have gone: Previous approaches to proximity proteomics and SPR have mapped protein interactions, suggesting this path is promising but technically challenging.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Shi, Yi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Shi, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.