Mapping how genetic variants affect heart health
Systematically mapping variant effects for cardiovascular genes
This study is looking at how certain genes affect heart diseases to help doctors better understand and treat these conditions, making it easier for patients to manage their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10893541 on NIH RePORTER |
What this research studies
This research investigates the effects of genetic variants on cardiovascular diseases, which are major causes of death and disability worldwide. By utilizing advanced genetic sequencing and high-throughput cellular assays, the team aims to create a detailed atlas that maps the function of various genetic variants associated with heart conditions. This comprehensive approach will help clarify how these variants influence heart health and disease, ultimately improving clinical management and treatment options for patients. The research involves collaboration among leading scientists to ensure a thorough understanding of the genetic factors at play.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known genetic variants linked to cardiovascular diseases, particularly those under 11 years old.
Not a fit: Patients without any genetic predisposition to cardiovascular diseases or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment strategies for patients with cardiovascular diseases based on their genetic profiles.
How similar studies have performed: Previous research has shown promise in mapping genetic variants to disease outcomes, indicating that this approach could yield significant insights into cardiovascular health.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Roden, Dan M — Vanderbilt University Medical Center
- Study coordinator: Roden, Dan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.