Mapping how brain cells develop and function in humans
A regulome and transcriptome atlas of fetal and adult human neurogenesis
This study is looking at how new brain cells are made from before birth to adulthood, focusing on a key area that helps with memory and learning, to better understand brain cell differences and how they relate to conditions like Alzheimer's, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10377713 on NIH RePORTER |
What this research studies
This research investigates the processes of neurogenesis, which is the formation of new neurons in the human brain, from fetal development through adulthood. It focuses on understanding how transcription factors influence the development of brain cells, particularly in the dentate gyrus of the hippocampus, an area crucial for memory and learning. By utilizing advanced technologies to analyze gene expression and cellular organization, the study aims to uncover the complexities of brain cell diversity and its implications for neuropsychiatric conditions like Alzheimer's disease. Patients may benefit from insights gained about the mechanisms underlying these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those with or at risk for Alzheimer's disease.
Not a fit: Patients with neurodegenerative conditions unrelated to Alzheimer's or those under 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases such as Alzheimer's.
How similar studies have performed: Previous research has shown promising results in understanding neurogenesis and its relation to neuropsychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Roussos, Panagiotis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Roussos, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.