Mapping genetic variants that influence autoimmune diseases
Precision mapping of regulatory causal variants by expression CROPseq
This study is looking at how certain genetic differences can influence autoimmune diseases, with the goal of helping patients understand their unique genetic risks so they can receive more personalized treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11060045 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations affect the expression of genes related to autoimmune diseases. By using advanced techniques like CRISPR-Cas9 and single-cell genomics, the study aims to identify and validate causal variants within genetic regions linked to these conditions. Patients may benefit from a better understanding of their genetic predispositions, which could lead to more personalized treatment options. The research focuses on fine mapping these variants to improve disease management and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those who have a family history of such conditions.
Not a fit: Patients with non-autoimmune conditions or those without a genetic predisposition to autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more targeted therapies for autoimmune diseases based on individual genetic profiles.
How similar studies have performed: Previous research has shown success in using CRISPR and genomic mapping techniques to identify genetic variants associated with various diseases, indicating a promising approach.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Gibson, Gregory C — Georgia Institute of Technology
- Study coordinator: Gibson, Gregory C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.