Mapping genetic variants that affect immune system function
Official title: Multiscale genome engineering to map cis-regulatory variants in human and mouse
Funded at New York Genome Center · NIH-10930157 · Data updated 2026-11-12
This study is looking at how certain genes affect the immune system, especially T cells, which are important in autoimmune diseases, to help us better understand what goes wrong in these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,082,024 |
| NIH project number | 5R01HG012790-02 |
| Project ID | NIH-10930157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those who have a family history of such conditions.
✕Less likely to help
Patients without autoimmune diseases or those not genetically predisposed to these conditions may not benefit from this research.
What this research studies
This research investigates how specific genetic variants influence the regulation of genes involved in immune system function, particularly focusing on T cells, which play a crucial role in autoimmune diseases. By utilizing advanced genome engineering techniques, including CRISPR, the team aims to create detailed maps of genetic elements that control gene expression in T cells. The approach involves conducting high-throughput screens to identify key genes and regulatory elements, followed by in-depth analysis to understand their roles in immune responses. This research could provide insights into the biological mechanisms underlying autoimmune disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases by targeting specific genetic variants.
How similar studies have gone: Previous research using CRISPR and genome mapping techniques has shown promise in understanding genetic influences on various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Sanjana, Neville — New York Genome Center
- Study coordinator: Sanjana, Neville
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.