Mapping genetic variants that affect immune system function
Multiscale genome engineering to map cis-regulatory variants in human and mouse
['FUNDING_R01'] · NEW YORK GENOME CENTER · NIH-10930157
This study is looking at how certain genes affect the immune system, especially T cells, which are important in autoimmune diseases, to help us better understand what goes wrong in these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK GENOME CENTER (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10930157 on ClinicalTrials.gov |
What this research studies
This research investigates how specific genetic variants influence the regulation of genes involved in immune system function, particularly focusing on T cells, which play a crucial role in autoimmune diseases. By utilizing advanced genome engineering techniques, including CRISPR, the team aims to create detailed maps of genetic elements that control gene expression in T cells. The approach involves conducting high-throughput screens to identify key genes and regulatory elements, followed by in-depth analysis to understand their roles in immune responses. This research could provide insights into the biological mechanisms underlying autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those who have a family history of such conditions.
Not a fit: Patients without autoimmune diseases or those not genetically predisposed to these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases by targeting specific genetic variants.
How similar studies have performed: Previous research using CRISPR and genome mapping techniques has shown promise in understanding genetic influences on various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK GENOME CENTER — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANJANA, NEVILLE — NEW YORK GENOME CENTER
- Study coordinator: SANJANA, NEVILLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, Brittle Diabetes Mellitus