Mapping brain tissue around blood vessels to understand aging and Alzheimer's disease

Who could benefit from this research

What this research studies

This project will use high-resolution microscopy and immunohistochemistry to map the structure of the pia mater, the tissue around brain vessels, in humans. It will examine how this perivascular network changes with age and how those changes relate to Alzheimer’s pathology and other neurological measures. The study leverages ROSMAP resources to connect physical brain structure with clinical and pathological data. Results could illuminate new ways that brain clearance systems and blood vessel health influence dementia. The work is laboratory-based but directly tied to human brain tissue and aging.

Why it matters

Where this research is happening

• Rush University Medical Center
  Chicago, United States Active

Researchers

• Principal investigator: Mehta, Rupal I. — Rush University Medical Center
• Study coordinator: Mehta, Rupal I.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.