Mapping brain interactions related to Lewy pathology in synucleinopathy
PROTEOMIC MAPPING OF PATHOLOGICAL INTERACTIONS ACROSS THE SYNUCLEINOPATHY BRAIN
This study is looking at how certain brain changes happen in conditions like Parkinson's disease, using both human brain samples and animal models, to find new ways to help treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10860970 on NIH RePORTER |
What this research studies
This research investigates the cellular processes involved in the formation and clearance of Lewy pathology (LP) in the human brain, which is crucial for understanding synucleinopathies like Parkinson's disease. By utilizing innovative techniques to capture LP interactions in intact brain tissues, the study aims to identify the core molecular processes that contribute to the initiation and progression of these disorders. The research will involve both human brain samples and rodent models to comprehensively analyze these interactions across the neuroaxis. Ultimately, the goal is to uncover potential therapeutic targets for developing disease-modifying treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with synucleinopathies, such as Parkinson's disease or Lewy body dementia.
Not a fit: Patients with other types of neurodegenerative diseases that do not involve synucleinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the progression of synucleinopathies, improving outcomes for patients.
How similar studies have performed: While the approach of mapping LP interactions is innovative, similar studies have shown promise in understanding neurodegenerative diseases, suggesting potential for success.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Killinger, Bryan — Rush University Medical Center
- Study coordinator: Killinger, Bryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.