Mapping brain function and disorders in marmosets
Developing cell type-specific enhancers and connectivity mapping pipelines for marmosets
['FUNDING_OTHER'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-10653998
This study is exploring how the brains of common marmosets work by using new genetic tools, which could help us understand brain disorders better and find new ways to treat them in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10653998 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced genetic tools to study brain function and disorders in common marmosets, a type of non-human primate. By utilizing cutting-edge techniques like single cell RNA sequencing and ATAC sequencing, the project aims to identify specific genetic enhancers that are unique to different cell types in the marmoset brain. This approach will help create a detailed map of brain connectivity and enhance our understanding of higher cognitive functions that are not well modeled in rodents. The findings could lead to better insights into human brain disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological or psychiatric conditions that are poorly understood and lack effective treatments.
Not a fit: Patients with conditions that are primarily modeled in rodents or do not involve higher cognitive functions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain disorders that affect higher cognitive functions in humans.
How similar studies have performed: While the use of non-human primates in neuroscience is established, the specific approach of using marmosets and the techniques being applied are relatively novel and have not been extensively tested.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FENG, GUOPING — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: FENG, GUOPING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Encephalon Diseases, Intracranial CNS Disorders, Intracranial Central Nervous System Disorders