Making therapeutic herpes virus for glioblastoma
Core 1: oHSV Production Core
This project makes concentrated, clinical-grade oncolytic herpes viruses intended to help people with aggressive brain tumors like glioblastoma.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11181526 on NIH RePORTER |
What this research studies
This core produces and purifies engineered herpes simplex viruses that selectively target and kill glioblastoma cells while minimizing harm to normal brain tissue. The team develops scalable manufacturing and purification processes and makes both research-grade and cGMP-grade virus batches. These virus stocks are supplied to laboratory projects and to planned Phase I clinical trials studying delivery and safety in patients. If you want to learn about trials using these viruses, treating centers in the P01 network would handle screening and enrollment.
Who could benefit from this research
Good fit: Ideal candidates would be adults with recurrent or treatment-resistant glioblastoma who meet eligibility for oncolytic virus Phase I trials at participating centers.
Not a fit: People with cancers outside the brain, those who are severely immunocompromised, or individuals who do not meet surgical or eligibility criteria for oncolytic virus trials are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could enable safe, tumor-targeting viral therapies to enter clinical trials for people with glioblastoma.
How similar studies have performed: Other oncolytic herpesvirus approaches have shown promise in early clinical studies (including approvals in other cancers) and preliminary glioblastoma trials, so this builds on prior encouraging results.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Goins, William F. — Brigham and Women's Hospital
- Study coordinator: Goins, William F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.