Macrophages shaping inflammation and healing in mucosal tissues
Official title: Macrophage-mediated regulation of inflammation and tissue repair
Funded at Harvard Medical School · NIH-11519983 · Data updated 2026-11-12
This NIH grant explores how macrophages control inflammation and aid tissue repair in mucosal areas, with aim to improve how these tissues recover after damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $55,478 |
| NIH project number | 3R35GM150816-04S1 |
| Project ID | NIH-11519983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with mucosal injuries or diseases where epithelial repair and inflammation are key issues, such as viral infections affecting mucosal surfaces.
✕Less likely to help
People without mucosal injury or conditions related to mucosal repair may not directly benefit.
What this research studies
The project looks at how macrophages interact with epithelial cells after damage from viruses or chemicals in mucosal tissues. It uses live animal models and organoid systems to study how immune and epithelial cells talk to each other during inflammation and healing. The goal is to uncover new regulators of repair that could lead to better recovery after mucosal injury. This work could eventually inform therapies that promote efficient healing while keeping infection in check.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to enhance mucosal repair and prevent excessive inflammation.
How similar studies have gone: Previous research shows that macrophage-epithelial interactions influence healing, suggesting this line of study has translational potential but is still advancing.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Franklin, Ruth a — Harvard Medical School
- Study coordinator: Franklin, Ruth a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.